Objectives: to compare erythrocyte thiamine pyrophosphate concentrations in somewhat old people with those in healthy younger people; to determine if any differences can be attributed to age or to co-morbidities.

Objectives: to compare erythrocyte thiamine pyrophosphate concentrations in somewhat old people with those in healthy younger people; to determine if any differences can be attributed to age or to co-morbidities. Design: cross-sectional and 3-year longitudinal overlooks Setting: primary care. Patients: 100 tender blood donors and 222 somewhat old people from a general practice register. Measurements: thiamine pyrophosphate concentrations using high performance liquid chromatography; physical examination, medical and medication history; grip hardness body mass index and plasma albumin. Results: the mean [95% confidence interval (CI] thiamine pyrophosphate concentration was 152 nmol/l (147-158) in the somewhat old group and 224 (213-235) nmol/l in the younger collection (P < 0.001). Ninety-six (434%)of the somewhat old subjects had thiamine pyrophosphate concentrations below the fifth percentile of the younger bring under rules (140 nmol/l). Over 3 years thiamine pyrophosphate concentrations bring to the ground in the elderly cohort by means of 20% (95% CI: 14.5-24.5%; P < 001) Thiamine pyrophosphate concentrations in 39 healthy older family were no different from those in somewhat old people with co-morbidity but were significantly lower than those in the younger populace Elderly people with absent vibration mind in their feet had a lower thiamine pyrophosphate concentration than the quiescence of the group [129 (117-142)nmol/l compared with 156 (150-162)nmol/l; P < 001)] Thiamine pyrophosphate concentrations were not related to prevalent diseases, customary medications, body mass index, grip toughness or plasma albumin. Conclusion: lower thiamine pyrophosphate concentrations in somewhat old people appear to be related more to age itself than to co-existent illnesses.

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