Background: the optimum treatment for oropharyngeal candidosis.

Background: the optimum treatment for oropharyngeal candidosis, particularly in older patients, has not been established. Local treatment with nystatin and amphotericin B can be problematic. The oral suspension formulation of fluconazole may exhibit a good alternative to these conventional agents. Objective: to compare the safety and efficacy of fluconazole oral suspension with amphotericin B oral suspension in the treatment of older patients with oropharyngeal candidosis. Design: randomized open-label subject of attention Patients: three hundred and five patients, aged 62 or older with at least single sign or symptom of oropharyngeal candidosis. Methods: we evaluated patients for the signs and symptoms of candidosis before receiving the investigation drug and on days 4 7 and 14 We assessed patients who were cur or improved after 7-14 days of treatment 2 weeks after the period of treatment (follow-up). We obtained specimens from buccal lesions for microscopic examination (baseline only) and agriculture at baseline and on days 7 and 14 Patients were evaluated for adverse terminations on days 4, 7 and 14 Results: single hundred and fifty patients received fluconazole and 155 received amphotericin B There were no statistically significant differences in clinical or mycological replication between fluconazole and amphotericin B at the [i]finale[/i] of treatment or at follow-up At the finis of treatment, 122 (81%) of 150 fluconazole-treated and 135 (87%) of 155 amphotericin B-treated patients were clinically cur or improved. Mycological restoration rates were 35% and 46% for fluconazole and amphotericin B respectively. The symptoms of burning sensation and buccal pain resolv significantly sooner (P < 005) in fluconazole-treated patients. The vicinity of dentures did not affect the rejoinder to antifungal therapy. The incidence of adverse conclusions was 46% in the fluconazole arrange and 50% in the amphotericin B collection (not statistically significant). Conclusion: fluconazole oral suspension is a convenient therapeutic alternative to amphotericin B oral suspension in the treatment of older patients with oropharyngeal candidosis.

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