Presentation: a previously fit 80-year-old woman not awayed with a 2-week history of spontaneous and extensive bruising affecting all four limbs.Presentation: a previously fit 80-year-old woman not awayed with a 2-week history of spontaneous and extensive bruising affecting all four limbs. The severity was like that she required a transfusion of 8 units of kindred Results of investigations: a markedly protracted activated partial thromboplastin time which was single partially corrected with normal plasma; examples for lupus anticoagulant were negative. Factor VIII flats were reduced and the Bethesda assay indicated an acquired inhibitor to factor VIII. She was treated with a combination of intravenous immunoglobulin and immunosupression. Outcome: the rejoinder to treatment was excellent, with a marked reduction in anti-factor VIII antibody flushs and resolution of the bruising above the next few weeks. COPYRIGHT 2000 Oxford University Press |
| Home |
