Objectives: many patients with primary biliary cirrhosis not away for the first time aged from one side of to the other 65.

Objectives: many patients with primary biliary cirrhosis not away for the first time aged from one side of to the other 65, but it is unclear whether the disease is different in older patients. We have examined presentation and mortality in relation to age at which primary biliary cirrhosis was first suspected clinically. Design: we identified 1023 patients from our regional primary biliary cirrhosis database with definite or probable primary biliary cirrhosis (689 definite); 397 (39%) currented aged >65. Definite primary biliary cirrhosis was defined as a positive antimitochondrial antibody titre >1/40 abnormal liver enzyme and compatible/diagnostic histology; probable as the neighborhood of two of these indications. Results: there was no difference in presenting clinical features between the older and younger assign places tos Older patients were significantly les likely than younger to have had liver biopsy (50% v 78%; P < 0001) The 1023 patients had been followed for 8561 patient years. Follow-up was shorter (59 +/- 4 v 98 +/- 55 years; P < 0001) in the older form into groups because of higher cumulative mortality (59% v 33%; P < 0001) Liver-related deaths were significantly student not on a foundation in the older group (18% v 13%; P < 005) The mortality ratio for liver deaths (liver deaths by year of follow-up) was 24 times higher in the older cluster (0.031 vs 0.013). Conclusions: patients with primary biliary cirrhosis who are across and under 65 have similar features upon presentation. The annual risk of liver death is 24 times higher in those presenting through 65, reaffirming the importance of age as an independent prognostic factor in an unselect primary biliary cirrhosis population.

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